P75 neurotrophin receptor-mediated neuroprotection of NGF against glutamate neurotoxicity in coritcal cultures
نویسندگان
چکیده
منابع مشابه
Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.
BACKGROUND Propofol exposure to neurons during synaptogenesis results in apoptosis, leading to cognitive dysfunction in adulthood. Previous work from our laboratory showed that isoflurane neurotoxicity occurs through p75 neurotrophin receptor (p75(NTR)) and subsequent cytoskeleton depolymerization. Given that isoflurane and propofol both suppress neuronal activity, we hypothesized that propofol...
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Donepezil is a potent and selective acetylcholinesterase (AChE) inhibitor developed for the treatment of Alzheimer's disease. To elucidate whether donepezil shows neuroprotective action in addition to amelioration of cognitive deficits, we examined the effects of donepezil on glutamate-induced neurotoxicity using primary cultures of rat cortical neurons. A 10-min exposure of cultures to glutama...
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Yan Zhang,2,4 Yanguo Hong,4 Younes Bounhar,2,4 Megan Blacker,4 Xavier Roucou,4 Omar Tounekti,4 Emily Vereker,4 William J. Bowers,1 Howard J. Federoff,1 Cynthia G. Goodyer,3 and Andréa LeBlanc2,4 1Department of Neurology and Center for Aging and Developmental Biology, University of Rochester, Rochester, New York 14642, Departments of 2Neurology and Neurosurgery and 3Pediatrics, McGill University...
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In Reply:—It was an honor to read the response of Dr. Moore to my editorial about defining professionalism within anesthesiology. Dr. Moore’s comments are presented from the perspective of the President of the American Society of Anesthesiologists (ASA), highlighting several important issues not emphasized in my manuscript because of space constraints of the editorial format. The Lifeline Campa...
متن کاملCD 271 (P75 neurotrophin receptor).
P75NTR (or CD271) is a member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins that share significant homology in their extracellular domains. Subsets of TNF receptors, including CD271, have a cytoplasmic death domain, although CD271 has unique intracellular structure and downstream signaling partners. CD271 is also differentiated from other members of the TNF...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)41159-1